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Type: Ketorolac Tromethamine brand, Acular generic, Toradol generic
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Indications and usage:
Tablets
Acute pain in adult patients. Toradol (Ketorolac) oral tablets is indicated for the short-term ( >= 5 days) management of moderately severe acute pain that requires analgesia at the opioid level, usually in a postoperative setting. Therapy should always be initiated with IV or IM dosing of ketorolac tromethamine, and Toradol oral is to be used only as continuation treatment, if necessary.
The total combined duration of use of Toradol oral and ketorolac tromethamine is not to exceed 5 days of use because of the potential of increasing the frequency and severity of adverse reactions associated with the recommended doses. Patients should be switched to alternative analgesics as soon as possible, but Ketorolac tablets therapy is not to exceed 5 days.
Eye drops
Acular (Ketorolac) ophthalmic solution is a nonsteroidal, anti-inflammatory indicated for:
Contraindications:
Tablets
Toradol (Ketorolac) is contraindicated in patients with previously demonstrated hypersensitivity to ketorolac tromethamine. This medication is contraindicated in patients with active peptic ulcer disease, in patients with recent gastrointestinal bleeding or perforation and in patients with a history of peptic ulcer disease or gastrointestinal bleeding.
Toradol should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.
Eye drops
Hypersensitivity to any component of this product.
Dosage and administration:
Tablets
Patients age 17 to 64: 20 mg PO once followed by 10 mg q4-6 hours prn not > 40 mg/day.
Patients age >= 65, renally impaired, and/or weight < 50 kg (110 lbs): 10 mg PO once followed by 10 mg q4-6 hours prn not > 40 mg/day.
Note:
Total duration of treatment in adult patients: the combined duration of use of IV or IM dosing of ketorolac tromethamine and Toradol oral is not to exceed 5 days.
Eye drops
One drop of Acular (Ketorolac Tromethamine) should be applied to the affected eye(s) four times a day for relief of ocular itching due to seasonal allergic conjunctivitis.
For the treatment of postoperative inflammation in patients who have undergone cataract extraction, one drop of Acular should be applied to the affected eye four times daily beginning 24 hours after cataract surgery and continuing through the first 2 weeks of the postoperative period.
Dosage forms and strengths:
Tablets
Toradol (Ketorolac Tromethamine) 10 mg oral tablets are round, white, film-coated, red printed tablets. There is a large T printed on both sides of the tablet, with TORADOL on one side, and ROCHE on the other, available in bottles of 100 tablets.
Eye drops
Acular (Ketorolac Tromethamine) ophthalmic solution containing 5 mg/mL ketorolac tromethamine, 10 mL size bottle filled with 5 mL of solution.
Overdosage:
Tablets
Symptoms and signs: symptoms following acute NSAID (including Ketorolac) overdoses are usually limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which are generally reversible with supportive care. Gastrointestinal bleeding can occur. Hypertension, acute renal failure, respiratory depression and coma may occur, but are rare. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose.
Treatment: patients should be managed by symptomatic and supportive care following a NSAIDs overdose. There are no specific antidotes. Emesis and/or activated charcoal (60 g to 100 g in adults, 1 g/kg to 2 g/kg in children) and/or osmotic cathartic may be indicated in patients seen within 4 hours of ingestion with symptoms or following a large oral overdose (5 to 10 times the usual dose). Forced diuresis, alkalization of urine, hemodialysis or hemoperfusion may not be useful due to high protein binding. Single overdoses of Ketorolac Tromethamine have been variously associated with abdominal pain, nausea, vomiting, hyperventilation, peptic ulcers and/or erosive gastritis and renal dysfunction which have resolved after discontinuation of dosing.
Warnings and precautions:
Tablets
Eye drops
Drug interactions:
Ketorolac Tromethamine tablets interact with: warfarin, digoxin, salicylate, and heparin, aspirin, diuretics, probenecid, lithium, methotrexate, ACE inhibitors, angiotensin II receptor antagonists, antiepileptic drugs, psychoactive drugs, pentoxifylline, nondepolarizing muscle relaxants, selective serotonin reuptake inhibitors (SSRIs).
Related medications:
Bimatoprost (Lumigan, Careprost)
Adverse reactions, side effects:
Tablets
Adverse reaction rates increase with higher doses of Toradol (Ketorolac Tromethamine). Practitioners should be alert for the severe complications of treatment with Toradol, such as GI ulceration, bleeding and perforation, postoperative bleeding, acute renal failure, anaphylactic and anaphylactoid reactions and liver failure.
Eye drops
The most frequent adverse reactions reported by up to 40% of patients participating in clinical trials have been transient stinging and burning on instillation.
To report suspected adverse reactions, contact Allergan, Roche pharmaceutical companies or your local FDA.
Patient counseling information for Ketorolac ophthalmic solution:
Pregnancy
Because of the known effects of prostaglandin-inhibiting drugs on the fetal cardiovascular system (closure of the ductus arteriosus), the use of Acular solution during late pregnancy should be avoided.
Nursing mothers
Because many drugs are excreted in human milk, caution should be exercised when Acular (Ketorolac Tromethamine) eye drops is administered to a nursing woman.
Pediatric use
Safety and efficacy in pediatric patients below the age of 2 have not been established.
Geriatric use
No overall clinical differences in safety or effectiveness have been observed between elderly and other adult patients.
Patient counseling information for Ketorolac Tromethamine eye drops:
Slow or delayed healing
Patients should be informed of the possibility that slow or delayed healing may occur while using nonsteroidal anti-inflammatory drugs (NSAIDs).
Avoiding contamination of the product
Patients should be instructed to avoid allowing the tip of the bottle to contact the eye or surrounding structures because this could cause the tip to become contaminated by common bacteria known to cause ocular infections. Serious damage to the eye and subsequent loss of vision may result from using contaminated solutions.
Also, to avoid the potential for cross-contamination, the patient should be advised to use one bottle for each eye following bilateral ocular surgery. The use of the same bottle of topical eye drops for both eyes following bilateral ocular surgery is not recommended.
Contact lens wear
Patients should be advised that Acular solution should not be administered while wearing contact lenses.
Intercurrent ocular conditions reference
Patients should be advised that if they develop an intercurrent ocular condition (e.g., trauma or infection) or have ocular surgery, they should immediately seek their physician's advice concerning the continued use of Acular (Ketorolac Tromethamine) eye drops.
Concomitant topical ocular therapy
Patients should be advised that if more than one topical ophthalmic medication is being used, the medicines should be administered at least 5 minutes apart.
Where to buy ketorolac online:
To purchase Toradol, Acular (Ketorolac Tromethamine) tablets and ophthalmic solution from reliable online pharmacies and drugstores at low prices please use resources described above on this webpage.
Here is a list of popular medications containing ketorolac as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
| Trade name of the drug | Pharmaceutical forms and doses | Companies |
| Acular | ||
| Acuvail | ||
| Apo-Ketorolac | ||
| Ketanov | ||
| Ketlur | ||
| Lixidol | ||
| Sprix | ||
| Syndol | ||
| Toradol |
